There are only a few reasons GW Forensics (GWF) may have issues during operation.
You are not able to connect to the GroupWise system – Ensure that your GWF installation has access to the wpdomain.db.
You are not using a GroupWise Client 2014 or later.
You are not currently logged into GroupWise during operation of GWF.
Your Trusted Application Key is invalid and must be recreated.
User mailboxes are disabled.